World Stem Cells
World Stem Cells Clinic Cancun, Mexico
Specialty:
Chronic Diseases, Neurology, Robotic Surgery, Spine Care/Surgery, Stem Cell Therapy
Focus Area:
World Stem Cells, LLC. | Stem Cell Treatment | Alzheimer's | Parkinson's | Autism | Cerebral Palsy | Huntington's | Multiple Sclerosis | Lupus | Cancun, Mexico
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Date: 2024-11-03
Time: 15:30:00
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World Stem Cells Profile Overview
Stem cell research has now progressed dramatically and there are countless research studies published each year in scientific journals. Adult stem cells are already being used to treat many conditions such as heart disease and leukaemia. Researchers still have a long way to go before they completely control the regulation of stem cells. The potential is overwhelmingly positive and with continued support and research, scientists will ideally be able to harness the full power of stem cells to treat diseases that you or a loved one may suffer from one day.
At World Stem Cells, LLC advanced stem cell procedures are performed by our contract clinic and hospitals. Your Stem cells are tested, processed and data recorded at a state of the art facility, thus guaranteeing the highest level of quality and safety for our patients.
Our contract clinic provides stem cell treatments using bone marrow, adipose or cord blood derived stem cells. The stem cells are from the patient (autologous) or other donors (allogeneic) if cord blood is from someone, other than the patient. No fetal or embryonic stem cells are used to avoid the potential of adverse medical reactions such as graft vs. host disease and possible contaminants.
We provide facilitation services to the patient including communication between the patient, clinic and laboratory, technical information, and the collection of medical records and forms.
Our medical staff and clinical physicians review each patient’s chart before specifying the optimal stem cell treatment approach. The pre-treatment discussions takes advantage of the years of clinical experience, knowledge of the patients condition and personal situation, along with utilization of the most current literature in the field. Recognizing the unique nature and needs of our patients is critical to delivering the highest quality of services.
A partial listing of the conditions we treat successfully with stem cell therapies are listed below:
A partial listing of the conditions we treat successfully with stem cell therapies are listed below:
- Alzheimer’s
- Ankylosing Spondylitis
- Autism
- Celiac Disease
- Cerebral Palsy
- Charcot-Marie-Tooth Disease (CMT)
- Corneal Disease
- Crohn’s Diseases
- COPD
- Fuch’s disease
- Guillain-Barre’ Syndrome
- Hashimoto’s Thryroiditis
- Huntington’s Disease
- ITP
- Kidney Diseases
- Myasthenia Gravis
- Macular Degeneration
- Lupus (SLE)
- Multiple Sclerosis
- Osteoarthritis
- PAD
- Parkinson’s disease
- Psoriatic arthritis
- Sjogren’s Syndrome
- Rheumatoid Arthritis
- Scleroderma
- Stroke
- Ulcerative Colitis
If you would like more information on the treatment of a condition, request a free consultation by filling out the form in the left hand box. We look forward to the possibility of serving you.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
Please click here to request more information from World Stem Cells, LLC.
World Stem Cells, , Mexico Profile Details
We at World Stem Cells, LLC are striving to be anactive participant in finding therapeutic solutions for patients. Our commitment includes funding a state of the art laboratory, clinical trials, and the best treatment we can provide. This includes independent assessment and reporting for 2 years or greater post-treatment for all our patients. This will allow forand consistent advances in stem cell therapies internationally.
A partial listing of the conditions we treat successfully with stem cell therapies are listed below:
- Alzheimer’s
- Ankylosing Spondylitis
- Autism
- Celiac Disease
- Cerebral Palsy
- Charcot-Marie-Tooth Disease (CMT)
- Corneal Disease
- Crohn’s Diseases
- COPD
- Fuch’s disease
- Guillain-Barre’ Syndrome
- Hashimoto’s Thryroiditis
- Huntington’s Disease
- ITP
- Kidney Diseases
- Myasthenia Gravis
- Macular Degeneration
- Lupus (SLE)
- Multiple Sclerosis
- Osteoarthritis
- PAD
- Parkinson’s disease
- Psoriatic arthritis
- Sjogren’s Syndrome
- Rheumatoid Arthritis
- Scleroderma
- Stroke
- Ulcerative Colitis
If you would like more information on the treatment of a condition, request a free consultation by filling out the form in the left hand box. We look forward to the possibility of serving you.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
World Stem Cells Treatments Offered
A partial listing of the conditions we treat successfully with stem cell therapies are listed below:
- Alzheimer’s
- Ankylosing Spondylitis
- Autism
- Celiac Disease
- Cerebral Palsy
- Charcot-Marie-Tooth Disease (CMT)
- Corneal Disease
- Crohn’s Diseases
- COPD
- Fuch’s disease
- Guillain-Barre’ Syndrome
- Hashimoto’s Thryroiditis
- Huntington’s Disease
- ITP
- Kidney Diseases
- Myasthenia Gravis
- Macular Degeneration
- Lupus (SLE)
- Multiple Sclerosis
- Osteoarthritis
- PAD
- Parkinson’s disease
- Psoriatic arthritis
- Sjogren’s Syndrome
- Rheumatoid Arthritis
- Scleroderma
- Stroke
- Ulcerative Colitis
If you would like more information on the treatment of a condition, request a free consultation by filling out the form in the left hand box. We look forward to the possibility of serving you.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
Patient Management is a set of multidimensional requirements that are needed to address your total experience. In designing programs for our patients we began to first consider your medical needs and potentials for treatment.There are many avenues to pursue in achieving medical change. Our underlying belief is that an educated patient will ultimately achieve the greatest benefit. With that in mind, we took the time and resources to develop an educational site and make certain that appropriate and well-trained individuals answer your questions.
Please click here to request more information from World Stem Cells, LLC.
World Stem Cells Certificates, Accreditations, Qualifications Treatments Offered
CORPORATE TEAM
The team approach at World Stem Cells, LLC is unique from the perspective of having both an international flavor as well as some very seasoned staff members who have been in the field for most of their lives. The combination of both a functional medical approach along with a disciplined business approach insures an excellent patient experience.
Mr. Charles Newcomer, CEO
Mr. Newcomer first conceived of the idea of regenerative therapy in a genetics class in 1962 while attending Sophia University in Tokyo, Japan (a Jesuit University). Since that time he has followed stem cell development, the major contributors to the field, and has read and discussed hundreds of protocols honing his understanding of patient specific therapies. He and his corporations have received awards and recognition from city, county, states and the United State Congress.It is his goal to make World Stem Cells, LLC the leader in the patient management services business, thus allowing patients to receive the optimal stem cell treatments available, worldwide.
Dr. Alan A. Kadish, President
Dr. Kadish is a graduate of Bastyr University, an accredited naturopathic medical school in Kenmore,Washington. He completed rotations with both naturopathic (N.D./N.M.D.) and allopathic (M.D./D.O.) physicians and is currently involved in medical education and research. He spent 26 years as a primary care provider at the Center of Health?, in Medford Oregon. Additional educational background includes an E.M.T. (Emergency Medical Technician) certification from Santa Rosa Junior College in California, a B.A. in Biology and Chemistry from Montclair University, New Jersey and a B.S. in Natural Health Sciences from Bastyr University, Washington. Dr. Kadish has additional training in the field of clinical ecology, nutrition and environmental intolerance (allergies). Multiple ACE (Achieving Clinical Excellence) programs were also completed by Dr. Kadish. Dr. Kadish has made numerous appearances in newsprint, radio, medical schools and professional medical organization lectures, along with television appearances and both internet and conventional radio, promoting health education and the utilization of natural methods, for both prevention and resolution of disease.
Mrs. Tomiko Newcomer, Company Secretary
Mrs. Newcomer has worked with Mr. Newcomer for 50 years, in laboratory settings, in retail, manufacturing and other commercial ventures. She performs duties in management, secretarial and accounting arenas. Tomiko is highly skilled at both people (HR) and money management. Her compassion for people makes her a perfect addition to our patient management business.
PATIENT MANAGEMENT TEAM
Colleen Powers, Care Coordination Director
Colleen has been a coordination director for most of her life, having 7 daughters. She has been the office manager representing and developing the customer care experience for an international boutique jewelry firm during the last 6 years. She possesses the patience and attention to detail that is essential for the coordination of our patients’ care. Her ability to make organization from chaos is impressive. The patient feedback is awesome as she takes the time to listen and make certain that the experience of medical care, while in a foreign country, is almost effortless. From your flight to your food and accommodations, Colleen will make your trip a smooth experience. At World Stem Cells, LLC. we recognize that your situation is unique and will require a personalized approach to truly satisfy you and your traveling companions’ needs and desires.
Rodolfo (Rudy) Lozano, Care Coordination Director
Rudy is our man in Cancun. He possesses excellent bi-lingual skills coupled with a working knowledge of hospital procedures and necessary care requirements. Being a native Mexican resident, his intimate familiarity with the customs, language and locations of necessary services has been invaluable. His manner with our patients has received numerous accolades, continually.
CLINIC TEAM
Dra. Sylvia M. Abblitt Luengas, President
Dra. Sylvia Abblitt is a Board Certified Hematologist & Oncologist. Her practice began in 1984 and has evolved to focus on the treatment of diseases utilizing the application of stem cells. Her background includes stem cell use for 20+ years, for her oncology patients. She has treated multiple types of diseases, with stem cells, during the last number of years as the scientific literature and protocols matured. She is currently the director of hematology at both hospitals, Galenia and Amerimed in Cancun, Mexico and was the Vice President of the National Commission of Blood Banks in Mexico. Her memberships include the American Association of Blood Banks (AABB), Mexican Society of Transfusional Medicine, InterAmerica Society of Transfusional Medicine, Mexican Association for Studies of Hematology. Her team of specialists includes a growing family of physicians and therapists devoted to superb delivery of health care, utilizing cellular medicine.
Dra. Irene Olhovich Greene
Dra. Olhovich is a pediatric ophthalmologic surgical specialist who has been practicing for 28 years. She has taught at a number of prestigious universities, including National University of Mexico, La Salle University and Polytechnic National University in Mexico City. Currently she practices in both a private and hospital based setting.Her writings include ophthalmologic subjects both for adults and children. We are honored to have Dra. Olhovich as an active member of our board and as our ophthalmic specialist for care of our macular degeneration, Fuchs , and retinitis pigmentosa patient population.
Dr. Jose Luis Cruz Sanchez
Dr. Jose Luis Cruz Sanchez is a board certified anesthesiologist who has been in private practice since 2004.He is an assistant professor of anesthesiology for the medical residency programs at the regional general hospital no. 17, IMSS. Jose has been actively involved in the scientific technical committee, at the college of anesthesiology, in Quintana Roo. during the last two years. He also has participated for years as a member of the Synod council review of Mexican-based anesthesiology. He is currently on staff at the major primary private hospitals, here in Cancun. We have found his services to be of the highest quality and appreciate his being part of our clinical team.
Dr. Jorge M. Trevino
Dr. Jorge M. Trevino Graduate School of Medicine, Universidad La Salle in Mexico City, and then did a residency (specialty) in General Surgery at the Hospital General “Dr. Manuel Gea González” Secretary of Health in Mexico City. Subsequently had a formal US fellowship training in Advanced Laparoscopic Surgery at the Texas Endosurgery Institute in San Antonio, Texas, under the tutelage of Dr. Morris E. Franklin. This internship focused on the laparoscopic approach in the abdominal cavity with special emphasis on disease of the colon, as well as extensive training in all types of laparoscopic surgery, including obesity surgery. Dr. Treviño has written numerous articles in national and international medical journals and is author of numerous chapters in medical books, including the chapter on laparoscopic colon surgery in the textbook of choice for surgeons: “Mastery of Surgery” in the most recent release. He has authored numerous scientific articles and book chapters, and is often invited as speaker in conferences or performing live surgery as part of training in advanced laparoscopic surgery worldwide. Dr. Treviño has attended more than 200 conferences worldwide, as a visiting professor, speaker and as a Congressman, periodically providing live surgery for demonstrations. He is currently the President of the College of Surgery of Quintana Roo. and is frequently interviewed by magazines and general media (TV, Radio, etc.).
Dra. Maria Eugenia Hoz Baranda
Dra. María Eugenia Hoz Baranda is a plastic surgical specialist. Her medical training includes a medical degree from the eminent, Universidad La Salle in Mexico City, and her?specialty training fellowship in Plastic and Reconstructive Surgery, at the Hospital of Mexico’s Secretary of Health, 6.An additional fellowship, specific to breast surgery, was done at the Plastic Surgery Clinic of Dr. Rafael de la Plaza in Madrid, Spain. She is certified by the Mexican Council of Plastic and Reconstructive Surgery and an active member of the Mexican Association of Plastic, Aesthetic and Reconstructive Surgeons , the Association of Resident Doctors and Non Resident “Fernando Ortiz Monastery” and the Association of Residents and Non Residents at the General Hospital of Mexico. Dr. Hoz is a founding member and current Vice President of the College Association of Aesthetic and Reconstructive Plastic Surgeons, of Quintana Roo. Her more than 20 years of experience in cosmetic and reconstructive surgery is a welcome addition to our team of specialty physicians.
Dr. Vladimir H. Ruiz Ronquillo
Dr. Vladimir H. Ruiz Ronquillo is a cardiologist with a subspecialty in interventional cardiology hemodynamics. He graduated from the Cardiology Hospital National Medical Center Siglo XXI, of the IMSS cardiology program, with honors, in 2006. His medical school training includes a residency between 2003 to 2006 at the Universidad National Autonoma de Mexico, and certification in Clinical Cardiology and Interventional Cardiology in 2008. This rigorous program is recognized by the Society of Cardiology as the most prestigious internationally. His medical school training includes a residency between 2003 to 2006 at the Universidad National Autonoma de Mexico, and certification in Clinical Cardiology and Interventional Cardiology in 2008. This rigorous program is recognized by the Society of Cardiology as the most prestigious internationally. Dr. Ruiz is associated with Galenia and Hospital Amerimed Cancun, along with Passport Medical Group, Costa Med and Centro Medico de Cozumel.
Dra. Martha Schutte Isabela
Dr. Schutte is a general surgeon who graduated in 2002. She then continued her studies to specialize in anesthesiology, with a subspecialty in pain management. She currently is employed at the Zone General Hospital No. 3 in the Mexican Social Security Institute (IMSS)., Anesthesiologist Medical Clinic at the Mexican Institute for State Workers (ISSSTE) and the Pain Clinic and Palliative Care at Amerimed Hospital. She is a member of the Federation of College Mexico in Anesthesiology.
Dra. Silvia Chichil Garcia
Dr. Silvia Chichil Garcia graduated from the Universidad Autonoma de Mexico as a medical surgeon in 1995. She then continued with her specialty training, in anesthesiology, at the Medical Center Siglo XXI. Currently Dr. Chichil is employed by both the Mexican Institute of Social Security and is in private practice.
Aurora Noemi Lozano Zepeda, PT
Aurora was trained at the School of Physical Medicine “Adele Ann Yglesias” ABC Hospital. She graduated with a degree in Physical Therapy and Rehabilitation. This 4-year hospital training is based on the English method of instruction. This includes an excellent overview of both traditional physical therapy coupled with occupational therapy. In addition Aurora has taken multiple courses to continue her education including lumbo-pelvic stabilization, addressing rotator cuff injury, soft tissue therapy for the cervical and dorsal spine, updates on cerebral palsy, management of child amputees, and consideration of sexuality in the handicapped patient. She holds ACLS certification and has been in practice for 18 years in both private and hospital settings. Aurora has been a speaker at the Cardiac Rehabilitation Seminar in Mexico City, lecturing on “Passive mobilization in the critically ill patient”. Her clientele include both high performance athletes to severely incapacitated patients. The style of therapy is very much a hands on, lead by example, based approach. Additional educational materials are individually customized to address the specific needs of her patients.
Please click here to request more information from World Stem Cells, LLC.
World Stem Cells Testimonials
Hello Dr. Kadish,
When we came from Cancun the first week we noticed an improvement in eye contact. It improved about 70%. His attention improved about 50% and he was more in our world when it comes to understand what it happening around him. He lost some of his attention for the last two weeks but it is still better than it was prior stem cells and even Janik BIs therapist say it is easier to work with Janik in ABA because his eye contact is better and his focus is also better.”
Owen is happy again
Well Owen is happy again, which is the biggest improvement. He is laughing and giggling again. His eye contact has improved and he is playing with toys again. All of these things had stopped. I`m so happy that he is happy. (His Mom)
Owen is happy again
Well Owen is happy again, which is the biggest improvement. He is laughing and giggling again. His eye contact has improved and he is playing with toys again. All of these things had stopped. I`m so happy that he is happy. (His Mom)
Please click here to request more information from World Stem Cells, LLC.
World Stem Cells Awards & Recognitions
Tissue Degeneration, Aging and Mitochondrial Dysfunction
January 03, 2012
Tissue Degeneration Found In Aging Is Partially Caused By Mitochondrial Dysfunction In Stem Cells
Comments by Dr. Kadish: This is an excellent overview of one of the may avenues of aging that will create an environment that results is what is known as oxidative stress. This occurs when we fail to eat properly use certain medications and have adverse exposures to toxic materials.
There are clear indications that certain vitamins can be asissitve in reducing and even regenerating the oxidized tissue back to a more normal health state. consider your life style and the results, from a long term prospective.
Research models have preciously found that an accumulation of mitochondrial genome defects leads to symptoms of premature aging: thin skin, graying of hair, baldness, osteoporosis and anemia.
In a breakthrough revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance, new research on the mechanisms of age-associated degeneration indicates that tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. Stem cell function may be modified with the result that progeny cells in blood and the nervous system are dysfunctional.
Mitochondria are the cellular engine: they transform the energy of nutrients to a form that cells can use, and in this process they burn most of oxygen we inhale. If this nutrient ‘burning’ is inefficient, the engine will produce oxygen radicals that damage cellular structures, including the genome. The researchers also found that these defects could be partially prevented by early antioxidant treatment.
“This suggests that oxygen radicals can regulate stem cell function and that these cells are very susceptible for mitochondrial dysfunction. These findings may also be important to understand mechanisms of mitochondrial disease”, said Professor Anu Suomalainen Wartiovaara of Helsinki University. His team collaborated in the research with researchers at Max Planck Institute for Biology of Aging, Karolinska Institute and the University of Wisconsin.
Researchers Remove Potential Tumor Causing Stem Cells
September 09, 2011
Researchers Discover Method Of Removing Potential Tumor-Causing Stem Cells From Cells Developed For Use In Medical Treatments
Comments by Dr. Kadish: The keynote of this article addresses one of the issues facing the safe use of modified stem cells to create specific other cells, without inducing an added risk. The use of a plant based separation approach is very intriguing and will require further work to become marketable, however is very much an interesting avenue for exploration.
Effective tricks for separating stem cells from other types are essential for many emerging medical treatments. These treatment approaches begin with researchers inducing stem cells to take specific forms, or differentiate, for instance into nerve cells. These differentiated cells might then be used to repair a spinal cord injury. Other cells might enable a diabetic’s body to produce adequate insulin.
A key problem is that in the differentiation process, at least some stem cells inevitably remain in their undifferentiated, or pluripotent, state. These cells can grow to form tumors in patients if injected along with differentiated cells, a concern that has already led the US Food and Drug Administration (FDA) to delay clinical trials for promising stem cell-based therapies.
So far almost all attempts at purification have focused on developing antibodies—immune system attack cells—that can remove or destroy stem cells in mixtures. But this approach has had shortcomings. Effective antibodies are difficult and expensive to develop, and their use in medical therapies raises safety issues because they are produced in animals.
Recently researchers have begun experimenting with chip-based tools known as lectin arrays. At various points on these devices, plant-produced proteins called lectins are attached. These lectins bind with specific sugars including some found on the surface of cells.
Working in the lab with cellular components, rather than whole cells, researchers at Scripps Research Institute, led by Professor of Developmental Neurobiology Jeanne Loring, found that specific combinations of sugars and proteins known as glycoproteins on stem cells reliably bind to certain lectins. They were then able to exploit this connection to purify cell mixtures.
After identifying the lectin that bound best with stem cells, the group took the work to the next level to show that they could actually separate out stem cells. To accomplish this, they first attached the lectin to tiny beads. Then they exposed these beads to mixtures of stem cells along with non-stem cells.
The researchers used a range of different types of both embryonic stem cells and induced pluripotent cells, which are embryonic stem cell-like cells that are produced by inserting certain genes into skin cells. They included cell lines from both Scripps Research and the labs of their collaborators in Japan and the United States.
In every case, the researchers found that the stem cells bound remarkably well to the beads, while the cells that washed past were almost all non-stem cells.
Possible uses for the new technique are essentially as numerous as those for stem cells themselves. Lectin purification could be used with any of a huge range of therapies currently in development. In addition to low cost and reliability, the lectins used are plant products, so they do not introduce the type of safety concerns that could arise from using antibodies that are produced by animal cells.
The Loring team is also working to identify different binding patterns that would allow them to similarly purify mixtures of specific types of non-stem cells. “In theory, this should allow us to pull any cell type out of any mixture,” she said of the basic lectin technique.
At the more basic research level, because all the different stem cell lines from both humans and animals seem to produce similar glycoproteins binding to the lectins, it is possible these glycoproteins infer some basic qualities fundamental to the pluripotent state. Loring and her colleagues are exploring this possibility in hopes of better understanding stem cells’ still mysterious abilities to transform into any type of cell. “We may have uncovered something really fundamental about pluripotency,” said Loring.
Adapted from the Scripps Research Institute announcement.
January 03, 2012
Tissue Degeneration Found In Aging Is Partially Caused By Mitochondrial Dysfunction In Stem Cells
Comments by Dr. Kadish: This is an excellent overview of one of the may avenues of aging that will create an environment that results is what is known as oxidative stress. This occurs when we fail to eat properly use certain medications and have adverse exposures to toxic materials.
There are clear indications that certain vitamins can be asissitve in reducing and even regenerating the oxidized tissue back to a more normal health state. consider your life style and the results, from a long term prospective.
Research models have preciously found that an accumulation of mitochondrial genome defects leads to symptoms of premature aging: thin skin, graying of hair, baldness, osteoporosis and anemia.
In a breakthrough revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance, new research on the mechanisms of age-associated degeneration indicates that tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. Stem cell function may be modified with the result that progeny cells in blood and the nervous system are dysfunctional.
Mitochondria are the cellular engine: they transform the energy of nutrients to a form that cells can use, and in this process they burn most of oxygen we inhale. If this nutrient ‘burning’ is inefficient, the engine will produce oxygen radicals that damage cellular structures, including the genome. The researchers also found that these defects could be partially prevented by early antioxidant treatment.
“This suggests that oxygen radicals can regulate stem cell function and that these cells are very susceptible for mitochondrial dysfunction. These findings may also be important to understand mechanisms of mitochondrial disease”, said Professor Anu Suomalainen Wartiovaara of Helsinki University. His team collaborated in the research with researchers at Max Planck Institute for Biology of Aging, Karolinska Institute and the University of Wisconsin.
Researchers Remove Potential Tumor Causing Stem Cells
September 09, 2011
Researchers Discover Method Of Removing Potential Tumor-Causing Stem Cells From Cells Developed For Use In Medical Treatments
Comments by Dr. Kadish: The keynote of this article addresses one of the issues facing the safe use of modified stem cells to create specific other cells, without inducing an added risk. The use of a plant based separation approach is very intriguing and will require further work to become marketable, however is very much an interesting avenue for exploration.
Effective tricks for separating stem cells from other types are essential for many emerging medical treatments. These treatment approaches begin with researchers inducing stem cells to take specific forms, or differentiate, for instance into nerve cells. These differentiated cells might then be used to repair a spinal cord injury. Other cells might enable a diabetic’s body to produce adequate insulin.
A key problem is that in the differentiation process, at least some stem cells inevitably remain in their undifferentiated, or pluripotent, state. These cells can grow to form tumors in patients if injected along with differentiated cells, a concern that has already led the US Food and Drug Administration (FDA) to delay clinical trials for promising stem cell-based therapies.
So far almost all attempts at purification have focused on developing antibodies—immune system attack cells—that can remove or destroy stem cells in mixtures. But this approach has had shortcomings. Effective antibodies are difficult and expensive to develop, and their use in medical therapies raises safety issues because they are produced in animals.
Recently researchers have begun experimenting with chip-based tools known as lectin arrays. At various points on these devices, plant-produced proteins called lectins are attached. These lectins bind with specific sugars including some found on the surface of cells.
Working in the lab with cellular components, rather than whole cells, researchers at Scripps Research Institute, led by Professor of Developmental Neurobiology Jeanne Loring, found that specific combinations of sugars and proteins known as glycoproteins on stem cells reliably bind to certain lectins. They were then able to exploit this connection to purify cell mixtures.
After identifying the lectin that bound best with stem cells, the group took the work to the next level to show that they could actually separate out stem cells. To accomplish this, they first attached the lectin to tiny beads. Then they exposed these beads to mixtures of stem cells along with non-stem cells.
The researchers used a range of different types of both embryonic stem cells and induced pluripotent cells, which are embryonic stem cell-like cells that are produced by inserting certain genes into skin cells. They included cell lines from both Scripps Research and the labs of their collaborators in Japan and the United States.
In every case, the researchers found that the stem cells bound remarkably well to the beads, while the cells that washed past were almost all non-stem cells.
Possible uses for the new technique are essentially as numerous as those for stem cells themselves. Lectin purification could be used with any of a huge range of therapies currently in development. In addition to low cost and reliability, the lectins used are plant products, so they do not introduce the type of safety concerns that could arise from using antibodies that are produced by animal cells.
The Loring team is also working to identify different binding patterns that would allow them to similarly purify mixtures of specific types of non-stem cells. “In theory, this should allow us to pull any cell type out of any mixture,” she said of the basic lectin technique.
At the more basic research level, because all the different stem cell lines from both humans and animals seem to produce similar glycoproteins binding to the lectins, it is possible these glycoproteins infer some basic qualities fundamental to the pluripotent state. Loring and her colleagues are exploring this possibility in hopes of better understanding stem cells’ still mysterious abilities to transform into any type of cell. “We may have uncovered something really fundamental about pluripotency,” said Loring.
Adapted from the Scripps Research Institute announcement.
Please click here to request more information from World Stem Cells, LLC.
, Mexico Destination Overview
World Stem Cells, LLC will provide advice and assistance regarding your travel, food and lodging options. This safe and pleasant environment, in Cancun, will accord you an opportunity to focus on your health. You will be accompanied throughout the treatment period by our care coordinators, all of whom are bilingual. We endeavor to make your travel and stay an easy and comfortable experience.
The International Cellular Medical Society (ICMS) together with World Stem Cells, LLC will maintain contact with our patients post stem cell treatment. The results, without your personal identification, will be used to advance research in the field of stem cell technologies. This transparent and open access to information is essential for patient safety and the advancement of the science.
Our staff is always easily available to insure your experience is both medically and comfort optimized. We look forward to changing the course of your disease.
Please click here to request more information from World Stem Cells, LLC.